Impact of ABCB1 single nucleotide polymorphisms 1236C greater than T and 2677G greater than T on overall survival in FLT3 wild-type de novo AML patients with normal karyotype
نویسندگان
چکیده
Ingrid Jakobsen Falk, Anna Fyrberg, Esbjorn Paul, Hareth Nahi, Monica Hermanson, Richard Rosenquist, Martin Hoglund, Lars Palmqvist, Dick Stockelberg, Yuan Wei, Henrik Green and Kourosh Lotfi, Impact of ABCB1 single nucleotide polymorphisms 1236C greater than T and 2677G greater than T on overall survival in FLT3 wild-type de novo AML patients with normal karyotype, 2014, British Journal of Haematology, (167), 5, 671-680. http://dx.doi.org/10.1111/bjh.13097 Copyright: Wiley: 12 months http://eu.wiley.com/WileyCDA/
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Impact of ABCB1 1236C > T-2677G > T-3435C > T polymorphisms on the anti-proliferative activity of imatinib, nilotinib, dasatinib and ponatinib
Overexpression of ABCB1 (also called P-glycoprotein) confers resistance to multiple anticancer drugs, including tyrosine kinase inhibitors (TKIs). Several ABCB1 single nucleotide polymorphisms affect the transporter activity. The most common ABCB1 variants are 1236C > T, 2677G > T, 3435C > T and have been associated with clinical response to imatinib in chronic myelogenous leukaemia (CML) in so...
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